Testing a new cholesterol drug in children with high cholesterol
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial tests if a new medicine, lerodalcibep, can safely lower cholesterol in children ages 6 to 17 who have a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to help children whose cholesterol stays high despite taking standard cholesterol-lowering drugs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 6 and 17 years old.
- You weigh more than 40 pounds (18 kg) and have a BMI between 17 and 42.
- You have been diagnosed with heterozygous familial hypercholesterolemia (HeFH).
- Your LDL cholesterol is 130 mg/dL or higher, even with current cholesterol medications.
- You must be on a stable diet and cholesterol medications for at least 6 weeks.
- If you are sexually active, you must use effective birth control (girls) or agree to use condoms or other contraception (boys).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a medicine called inclisiran to lower high cholesterol in children ages 6 to 12 with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It may help children who still have high cholesterol despite taking other treatments.
This study looks at children who may have inherited high cholesterol, especially when one parent is affected. It may help doctors detect the condition earlier and understand how it runs in families.
This study is a long-term follow-up for children and teens with familial hypercholesterolemia (a genetic condition causing very high cholesterol) who have already completed a previous study. It tests the safety and effectiveness of an investigational drug called lerodalcibep over a longer period.
This trial tests an experimental medication called QLC7401 for people with a genetic condition that causes very high cholesterol. It aims to lower cholesterol levels safely and may be an option for those who need better control.
This study tests an experimental daily pill (enlicitide decanoate) that lowers LDL ('bad') cholesterol in children and teens with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to see if this medicine can safely help reduce their high cholesterol levels.
This trial aims to identify kids and teens who may have inherited high cholesterol (especially LDL) and may be at higher risk for early heart artery disease. It may help families learn about their risk and ensure the right follow-up and treatment plan.
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