Eye drops for dry eye from graft-versus-host disease
Part of Eyes & vision, Immune system & allergy clinical trials.
This study tests whether a new eye drop (rhPRG4) can safely reduce dry eye symptoms caused by graft-versus-host disease (GVHD). It compares the active drops to an inactive placebo to see if they provide better relief.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have been diagnosed with eye GVHD for at least 3 months.
- You currently use artificial tears for your dry eyes.
- Your eye dryness score is at least 40 out of 100 on a scale.
- You have not had eye surgery or used certain eye treatments in the past 30 days.
- You are willing to use reliable birth control if you could become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an eye drop solution for people with chronic dry eye caused by graft-versus-host disease after a stem cell transplant. It aims to see if the drops can reduce eye discomfort and improve the eye surface.
This trial tests a new eye drop made from a natural protein (rhPRG4) to see if it safely and effectively relieves dry eye symptoms in people with Sjögren's syndrome. You'll be randomly assigned to receive the study drop or a placebo (inactive) drop for several weeks.
This study looks at how common and how severe corneal nerve-related dryness is in people with chronic graft-vs-host disease (GVHD) after a stem cell transplant. It may help doctors understand which eye problems are most typical and how best to recognize them early.
This trial tests if gentle electrical stimulation around the eye can help relieve dry eye symptoms caused by chronic graft versus host disease (a complication after a stem cell or bone marrow transplant). It is for people with moderate to severe dry eye who have not had recent eye surgeries or certain other eye problems.
This trial tests whether stem cell injections into the eye can help people with severe dry eye caused by graft-versus-host disease that hasn't gotten better with standard treatments. It aims to reduce eye pain and improve vision.
This trial tests whether eye drops made from a small sample of your own blood can relieve the symptoms of severe dry eye disease. The drops are meant to help eyes that have not improved with standard treatments.
Hear when a new Ocular Graft Versus Host Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.