Checking if early skull surgery helps after a major stroke
Part of Brain & nervous system, Heart & circulation clinical trials.
This study looks at whether doing a surgery to remove part of the skull (decompressive hemicraniectomy) soon after removing a large blood clot from the brain helps people who have had a very severe stroke. It is for people who have had a stroke caused by a blockage in a major artery and have already had a procedure to open that artery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have had a very severe stroke in one side of the brain, affecting the middle cerebral artery or internal carotid artery.
- You must be between 18 and 75 years old.
- You must have had a procedure to remove the clot (mechanical thrombectomy) within 24 hours of when you were last seen well.
- You must be able to have the skull surgery within 6 hours after the clot removal procedure.
- You must not have any major bleeding in the brain or other serious brain diseases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether emergency clot removal (endovascular therapy) can help people whose mild stroke gets worse within a week. It's for those who have a blockage in a large brain artery and enough healthy brain tissue to save.
This trial tests a surgical rescue treatment for people who have had a major stroke from a large artery blockage, but the standard clot removal procedure (thrombectomy) did not fully open the artery. The goal is to see if combining surgery with the earlier procedure can improve outcomes.
This study tests a procedure called endovascular recanalization, which uses a small tube to open a blocked artery in the brain. It is for people who had a stroke or mini-stroke recently and are still having symptoms despite taking medication. The goal is to improve blood flow and reduce the chance of another stroke.
This trial compares a procedure to remove a blood clot from a brain artery (endovascular therapy) with standard medicines alone, for people who had a large-vessel stroke more than 24 hours ago (up to 30 days). It aims to see if the procedure can still help improve recovery even after this longer time window, especially if symptoms are fluctuating or worsening.
This trial compares a procedure to remove a large blood clot from the brain (thrombectomy) with standard medical care for people who had a stroke 24 to 72 hours ago but still have some blood flow around the clot. It aims to see if the procedure can help improve recovery even when started later than usual.
This study looks at how the body's immune system reacts after a severe stroke that requires surgery to remove part of the skull. It may help doctors understand and manage stroke recovery better.
Hear when a new Cerebral Edema trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.