Atherectomy plus balloon versus balloon alone for severe leg-artery disease
Part of Heart & circulation clinical trials.
This trial compares two ways to open blocked leg arteries in people with severe limb-threatening ischemia. One method uses a special device to remove the plaque (atherectomy) followed by a balloon, and the other uses only a balloon. The goal is to see which approach better restores blood flow to the foot and helps wounds heal.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have severe leg artery disease (chronic limb-threatening ischemia) that is causing pain at rest or wounds that won't heal.
- The blockage must be in the smaller arteries below the knee (tibial arteries).
- The blockage must be either new (never treated) or have come back after a previous balloon angioplasty.
- The tibial artery must be at least 2 mm wide, and the part of the artery that goes to the foot must be open.
- You must not have had previous bypass surgery or atherectomy on the same leg, and no other significant blockages in the larger leg arteries.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares opening up one versus multiple blood vessels below the knee to improve blood flow in people with severe leg pain or wounds. It aims to find the best approach to save the limb and improve quality of life.
This study tests a new way to restore blood flow in the lower leg for people with chronic limb-threatening ischemia, a serious condition where leg wounds won't heal due to poor circulation. If it works, this treatment could help save the leg and avoid amputation.
This trial tests a special balloon that releases medicine to open blocked arteries below the knee in people with severe leg pain or wounds. It may help improve blood flow and avoid amputation.
This study compares using a laser device (Auryon) plus balloon angioplasty versus balloon angioplasty alone to open blocked arteries in the lower leg. The goal is to improve blood flow and reduce pain or heal sores in people with advanced peripheral artery disease.
This trial tests a two-step treatment for long blockages in the leg artery: first, a device clears the plaque, then a drug-coated balloon is used to keep the artery open and prevent re-narrowing. It aims to improve blood flow and reduce symptoms like leg pain or wounds.
This study compares two ways to treat complex blockages in the thigh/knee artery: using atherectomy followed by a medicated balloon versus using a medicated balloon by itself. It may help your care team learn which approach works best to open the artery and improve leg symptoms.
Hear when a new Chronic Limb-Threatening Ischemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.