Testing a drug to reduce bleeding during knee replacement
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial tests an experimental drug called BT-114143 to see if it reduces bleeding during and after total knee replacement surgery. It may be a good option for people with osteoarthritis who are having their first knee replacement.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old
- You have osteoarthritis in your knee and are scheduled for a total knee replacement
- Your knee deformity is mild (bending or bowing less than 15-20 degrees)
- You have not taken blood thinners (like aspirin, warfarin) in the week before surgery
- You are not planning any other surgeries within the next month
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether taking tranexamic acid for up to seven days after knee replacement surgery can reduce swelling, pain, and the need for pain pills. It may help you recover more comfortably after your operation.
This study tests whether putting tranexamic acid (a medicine that helps blood clot) directly into the bone during knee replacement surgery can reduce blood loss. It may help people recover with less need for blood transfusions.
This study measures how a medicine called tranexamic acid (which helps reduce bleeding) works when given through a needle in the bone versus in a vein during hip or knee replacement surgery. It may help your surgeon choose the best way to control bleeding during your operation.
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
This study tests whether taking tranexamic acid (a medication that helps blood clot) for a few days after knee replacement surgery can reduce bleeding and the need for blood transfusions. It may help patients recover with fewer complications.
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hear when a new Total Knee Arthroplasty trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.