Closed-loop deep brain stimulation for long-lasting depression
Part of Mental health clinical trials.
This study tests a special kind of brain stimulation that can adjust to your brain signals while treating major depression that has not improved with standard treatments. It may help people with severe, long-term treatment-resistant depression, but it requires brain surgery and frequent visits.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Ages 22 to 70
- You have long-lasting major depression and have tried many treatments without enough improvement, including ECT
- Your depression severity is high (MADRS score above 26) at both screening and starting the study
- You can safely have brain procedure planning and surgery, and you are willing to have brain monitoring/stimulation
- You must stay on your depression medicines unchanged for 4 weeks before and during the study
- You can attend multiple visits and also do at-home study tasks; you must speak and read English
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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