Chemotherapy and radiation before surgery for low rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests giving chemotherapy and radiation before surgery to people with advanced rectal cancer that is low in the rectum. The goal is to shrink the tumor enough to allow the surgeon to save the sphincter (the muscle that keeps you from leaking stool), so you might avoid a permanent colostomy bag.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have rectal cancer that has not spread to other parts of the body and is too advanced for local surgery alone.
- Your tumor is low in the rectum (within about 8 cm from the anal opening) or your surgeon says they can’t save your sphincter immediately.
- You want to try to save your sphincter and are willing to have regular check-ups for at least 2 years after treatment.
- You are healthy enough for surgery and have no other active cancers or serious uncontrolled medical conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new combination treatment (enverolimab plus standard chemotherapy) given before surgery for very low rectal cancer. The goal is to shrink the tumor so much that patients may avoid surgery and keep their rectum, but the study is for those who haven't had treatment before.
This trial tests combining standard chemotherapy and radiation with an immunotherapy drug (QL1706) before surgery for low rectal cancer. The goal is to see if this approach shrinks tumors more effectively and improves outcomes.
This trial tests whether giving chemotherapy and an immunotherapy drug before surgery can help shrink rectal cancer tumors and improve outcomes. It is for patients whose tumors are not caused by a specific genetic mismatch repair problem.
This trial tests a new combination of chemotherapy, radiation, and immunotherapy given before surgery for low rectal cancer. It aims to see if this approach can shrink tumors and improve outcomes for patients with a specific type of cancer that is microsatellite stable (MSS).
This trial tests whether people with early- to intermediate-stage low rectal cancer can avoid surgery if their tumor responds well to a full course of chemotherapy and radiation. It starts with brief chemotherapy, then adjusts treatment based on how much the tumor shrinks.
This study tests a sequence of chemotherapy and radiation before and after surgery for rectal cancer. It compares giving more chemo between the end of radiation and surgery (consolidation) versus giving some chemo before radiation starts (induction). The goal is to see which order works better.
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