Screening study for mast cell disease with KIT mutation
Part of Blood & lymphatic, Brain & nervous system, Cancer, Immune system & allergy, Skin clinical trials.
This study looks for a specific gene change (KIT D816V) in people with certain allergic reactions or related conditions. It aims to find those who might benefit from future treatments targeting this mutation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had a severe allergic reaction to insect stings or anaphylaxis without a clear cause.
- You have had a severe allergic reaction after eating meat like pork or beef, with a positive alpha-gal test.
- You have frequent symptoms like skin rashes, breathing issues, stomach problems, or heart palpitations that come and go without known triggers.
- You have a confirmed diagnosis of hEDS, hypermobility spectrum disorder, POTS with symptoms, or early-onset osteoporosis/osteopenia (under 50).
- You have a blood or bone marrow disorder like chronic myelomonocytic leukemia or a specific type of myelodysplastic/myeloproliferative neoplasm.
- You have mastocytosis in the skin without a known KIT mutation in blood or bone marrow, or you have cutaneous mastocytosis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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