Clin2
NCT07153770Possibly a fitNot yet recruiting

Bozitinib plus chemotherapy after surgery for MET-positive lung cancer

NSCLCMET Exon 14 MutationMET Activating Mutation

Part of Cancer, Lungs & breathing clinical trials.

This trial tests combining a targeted drug (bozitinib) with chemotherapy after lung cancer surgery to see if it can help prevent the cancer from coming back. The study is for people with a specific MET gene change in their lung cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
34 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 or older
  • You must have non-small cell lung cancer (adenocarcinoma) that shows a specific MET gene change
  • Your cancer must be stage IIA to IIIC, meaning it hasn't spread to distant organs
  • You must be able to have surgery to remove the cancer, and you must not have had chemotherapy or radiation before
  • Your overall health and organ function must be good enough (like normal blood counts, liver, kidney, and lung function)
  • You cannot have other treatable gene changes (like EGFR or ALK) or brain metastases

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06054191Not yet recruiting· Phase 2
Targeted treatment before and after surgery for lung cancer with BRAF or MET changes

This trial tests whether giving targeted therapy before and after surgery helps people with a specific type of lung cancer (non-small cell lung cancer with a BRAF or MET mutation). The goal is to see if this approach can shrink the tumor and improve outcomes.

Guangzhou, Guangdong
NCT06908993Recruiting· Phase 3
Tepotinib vs standard care for MET-mutated lung cancer

This trial tests a targeted pill called tepotinib against standard treatments for advanced lung cancer with a specific MET gene change. It is for people whose cancer has progressed after at least one prior therapy.

Besançon
NCT07156604Not yet recruiting· Phase 2
Vebreltinib before surgery for MET-mutant non-small cell lung cancer

This trial tests a targeted drug called vebreltinib given before surgery to people with a specific type of non-small cell lung cancer that has a MET gene change. The goal is to see if it can shrink the tumor enough to make surgery more successful.

Shanghai
NCT06930794Recruiting· Phase 3
Study of Vebreltinib Plus Chemo for MET-Positive Lung Cancer

This trial tests a targeted drug (Vebreltinib) combined with standard chemotherapy in people with a specific type of advanced non-squamous lung cancer that has a MET gene change (amplification or overexpression). The goal is to see if this combination works better than chemo alone.

Beijing, Beijing Municipality
NCT06644313Not yet recruiting· Phase 2
Vebreltinib before surgery for MET-altered lung cancer

This trial tests whether taking vebreltinib before surgery can help shrink lung cancer tumors with a specific genetic change (MET alteration). It may make surgery more effective for people with stage III non-small cell lung cancer.

NCT07549061Not yet recruiting· Phase 2
Vebreltinib plus chemotherapy for first-line MET-positive lung cancer

This trial tests a new targeted drug, vebreltinib, combined with standard chemotherapy as the first treatment for advanced non-small cell lung cancer that has a specific marker called MET overexpression. The goal is to see if this combination can help control the cancer better than chemotherapy alone.

Shanghai, Shanghai Municipality

Hear when a new MET Exon 14 Mutation trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.