Cooling artery treatment with magnesium for stroke clot removal
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests adding a cooled magnesium solution directly into the brain artery during standard clot removal to see if it helps limit brain damage and improve recovery. The magnesium and cooling aim to protect brain tissue while the clot is being taken out.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old
- You have had a stroke caused by a clot in a large artery in the front part of the brain
- Your stroke symptoms started within the last 24 hours and you are able to have a mechanical clot removal procedure
- Your stroke is moderately severe to severe (NIHSS score of 6 or higher)
- You were independent before the stroke (able to do daily activities without help)
- You do not have major bleeding risk, active infection, severe heart/lung/kidney/liver problems, or are pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if injecting a cooled magnesium sulfate solution into the brain artery, along with standard clot removal, can improve outcomes for people having a major stroke. The study focuses on strokes caused by a blockage in a large artery at the front of the brain within the past 24 hours.
This trial tests if giving magnesium into the brain's arteries after removing a clot can improve recovery from a stroke. It is meant for patients who have already had their large artery clot removed.
This trial tests a new treatment that combines cooling the brain with a catheter and removing the clot to restore blood flow — for people who have had a major stroke in the front part of the brain within the last 24 hours.
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This trial tests whether giving a clot-dissolving medication directly into the brain's blood vessels during a standard procedure (mechanical thrombectomy) can improve outcomes for people with a stroke caused by a blockage in a medium-sized artery. It may be an option for patients who arrive at the hospital within 24 hours of symptom onset and have enough salvageable brain tissue.
This trial tests if removing a large blood clot from the brain up to 3 days after a stroke improves recovery compared to standard medical care alone. It is for patients who have a severe stroke and are otherwise healthy enough for the procedure.
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