Clin2
NCT07185490Worth exploringNot yet recruiting

IASO104 Car-t therapy for relapsed multiple myeloma

Relapsed/Refractory Multiple Myeloma (RRMM)Plasma Cell Leukemia (PCL)

Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.

This trial tests a new CAR-T cell therapy (IASO104) for people whose multiple myeloma has come back or not responded to other treatments. It aims to see if this therapy can help reduce or eliminate the cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
40 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be between 18 and 75 years old.
  • You need a confirmed diagnosis of multiple myeloma or primary plasma cell leukemia.
  • You must have tried at least 3 prior treatments (or be resistant to certain drugs) for myeloma, or at least 1 prior treatment for primary plasma cell leukemia.
  • Your disease must have progressed within 12 months after your last treatment (unless your last treatment was CAR-T).
  • You need to have some measurable signs of disease, like a specific protein level in blood or urine, or a certain number of plasma cells in bone marrow.
  • You should be in generally good health (able to care for yourself, adequate organ function).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07322159Not yet recruiting· Early Phase 1
New cell therapy for relapsed or refractory multiple myeloma

This trial tests a new treatment called IASO206 for people with multiple myeloma that has come back or not responded to previous treatments. The therapy targets a protein called BCMA on myeloma cells, which may help control the disease.

NCT07509086Recruiting· Phase 2
Enhanced CAR-T therapy for relapsed multiple myeloma

This trial tests a new type of immune cell therapy (CAR-T cells boosted with a protein called IL-15) for people with multiple myeloma or plasma cell leukemia that has not responded to standard treatments or has come back. The goal is to see if these enhanced cells can better fight the cancer.

Changchun, Jilin
NCT07185477Not yet recruiting· Early Phase 1
Bispecific antibody plus CAR-T therapy for multiple myeloma

This study tests a two-step approach for people with relapsed or hard-to-treat multiple myeloma. First, you get a bispecific antibody (a drug that helps your immune system attack myeloma cells), then you receive CAR-T cell therapy (your own immune cells modified to fight the cancer). The goal is to see if this combination works well together.

NCT06333509Not yet recruiting· Phase 1/Phase 2
CAR-T cell therapy for relapsed or refractory multiple myeloma or plasma cell leukemia

This trial tests a new treatment called CAR-T cell therapy that uses your own immune cells to fight cancer. It is for people with multiple myeloma or plasma cell leukemia that has come back or not responded to other treatments.

NCT06999031Recruiting· Early Phase 1
CG-105-12 for relapsed/refractory multiple myeloma

This trial tests a new CAR-T cell therapy called CG-105-12 for people with multiple myeloma that has come back or stopped responding to other treatments. It aims to see if this therapy can help when at least 3 prior treatments have failed.

Nanchang, Jiangxi
NCT07611149Not yet recruiting· Phase 1
Car t-cell therapy for advanced multiple myeloma

This study tests a new type of immune cell therapy (CAR T-cells) for people with advanced multiple myeloma that has relapsed or not responded to standard treatments. The goal is to see if this therapy is safe and to understand its potential benefits.

Hear when a new Relapsed/Refractory Multiple Myeloma (RRMM) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.