Vitamin C and steroids for gut graft-versus-host disease
Treatments studied
Part of Immune system & allergy clinical trials.
This trial tests if adding vitamin C to standard steroid treatment helps control gut graft-versus-host disease (GVHD) after a stem cell transplant. It aims to reduce inflammation and improve symptoms in patients starting their first treatment for GI GVHD.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 5 years old or older.
- You have gut GVHD that needs treatment with steroids (this is your first episode or it's combined with skin GVHD).
- You are able to carry out daily activities (Karnofsky score 70% or higher).
- You have not taken more than 72 hours of steroids or ruxolitinib for this GVHD before joining.
- You do not have an uncontrolled infection, active cancer, or certain conditions like G6PD deficiency or sickle cell disease.
- You are willing to stay at the transplant center for follow-up.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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