Gastrointestinal clinical trials

Virtual reality program to reduce stomach-cancer pain

This trial tests whether virtual reality (VR) can improve pain and other day-to-day symptoms in people with certain gastrointestinal cancers. You’d use VR for pain relief while researchers measure how you’re feeling.

Ziftomenib and imatinib for advanced GIST

This trial tests a new drug, ziftomenib, combined with imatinib for people with advanced or spreading gastrointestinal stromal tumors (GIST) that have a KIT mutation. It may help if your GIST has gotten worse while on imatinib.

Best way to measure time during an upper GI endoscopy

This trial compares two ways of measuring time during an upper GI endoscopy (a camera test that looks at your esophagus, stomach, and the start of your small intestine) to see which one helps doctors find possible cancers better. The goal is to improve how these exams are done for people who need them for diagnosis or monitoring.

Surgery and tumor testing in gastrointestinal stromal tumors (GIST)

This study looks at how surgery for gastrointestinal stromal tumors (GIST) works, and collects tumor samples to study them under the microscope and by DNA testing. Your results may help researchers better predict tumor behavior and guide future treatment.

Imatinib plus atezolizumab versus imatinib alone for advanced GIST

This Phase 2 trial tests whether adding atezolizumab (an immune medicine) to imatinib works better than imatinib by itself in people with advanced gastrointestinal stromal tumors (GIST) that can’t be fully removed and have progressed after standard treatments. It may help by improving how well tumors respond and how long disease stays under control.

Remote symptom collection for better recovery after surgery

This trial uses a phone or computer app to track your symptoms after gastrointestinal tumor surgery. It aims to improve your recovery by keeping your care team informed remotely.

Creating an Image Database for Early Upper GI Cancer

This study aims to build a library of images from patients with early cancers or precancerous spots in the upper digestive tract (esophagus and stomach). If you are scheduled for a standard endoscopy procedure (ESD or biopsy), researchers will use the pictures to help improve early detection.

Dye-guided endoscopy to see gut blood vessels

This trial tests a new dye that lights up blood vessels in the gut during an endoscopy, using a special camera. It may help doctors see abnormal areas more clearly.

Abdominal massage for digestion in ICU patients on tube feeding

This study tests if gentle abdominal massage can improve digestion in intensive care patients who are on a breathing machine and receiving liquid food through a tube. It might help prevent gastrointestinal issues like bloating or slow digestion.

Check whether continuing imatinib works after long GIST control

This trial studies people with advanced or metastatic gastrointestinal stromal tumor (GIST) who have been on the drug imatinib for 10 years with stable, non-growing disease. The goal is to see how effective it is to keep imatinib going after this long period.

Radiation study for tumors that spread to soft tissue areas

This study looks at how a planned form of palliative radiation therapy treats certain solid cancers that have spread outside the brain to larger soft-tissue areas. It may help shrink tumors and relieve symptoms, but it also asks you to meet specific safety and treatment-timing rules.

Comparing a new ultrasound tool to the standard scope

This study compares a new, possibly easier-to-use ultrasound tool (EndoSound Vision System) to the standard echoendoscope for looking at organs like the pancreas, bile duct, or lymph nodes. If you are already scheduled for an endoscopic ultrasound, you may be able to join.

New Drug BHB810 for Advanced Stomach Cancer

This trial tests a new drug called BHB810 for gastric (stomach) and gastroesophageal junction cancer that has stopped responding to standard treatments or has no standard options available. The drug targets a protein called CDH17 found on cancer cells and may help slow or shrink the tumor.

Tegoprazan to prevent stomach problems after stroke

This study tests a stomach-protecting medicine called tegoprazan for people who have had a stroke and are starting antiplatelet therapy. It aims to prevent stomach complications like ulcers or bleeding.

Give blood and tumor samples for gastrointestinal cancer research

This trial collects blood and tumor tissue from adults with cancer to help researchers study gastrointestinal cancers. If you’re eligible, your participation mainly involves donating samples for research purposes.

Imaging checks on biopsy samples during routine scopes

This study uses special optical imaging during routine upper or lower endoscopy to look at biopsy tissue and compare what the images show with standard lab microscope results. It may help improve how doctors spot abnormal tissue during procedures.

Establishment of a Biological Collection to Develop Translational Preclinical Models for the Study of Tumors and Diseases of the Gastrointestinal Tract

Diet changes for children with eosinophilic gut disorders

This trial compares different elimination diets to see which one best reduces inflammation in children with eosinophilic gastrointestinal disorders. Your child might have fewer symptoms and a better outcome if the right diet is found.

New drug velzatinib versus imatinib for untreated GIST

This trial compares a newer cancer drug (velzatinib) with a standard treatment (imatinib) for gastrointestinal stromal tumors (GIST) that cannot be surgically removed or have spread. You would receive one of these two drugs to see which works better and is safer.

Testing a new drug plus chemo for stage 4 colorectal cancer

This study tests a new experimental drug (PF-08634404) combined with standard chemotherapy for people with stage 4 colorectal cancer who have not yet been treated for their advanced disease. The goal is to see if the combination helps shrink or slow the growth of tumors.

Guided Imagery App for Kids with Stomach Pain

This study tests a mobile app that uses guided imagery (a relaxation technique using your imagination) to help children ages 7–12 with stomach pain disorders. The goal is to see if the app is easy to use and helpful for managing pain.

KQB198 plus imatinib for advanced GIST

This trial tests a new drug called KQB198 combined with imatinib for people with advanced or metastatic gastrointestinal stromal tumor (GIST) that has a specific KIT or PDGFRA mutation. The goal is to see if this combination works better than imatinib alone as a first treatment.

Boosting gastrointestinal cancer screening for high-risk adults

This study tests a new way to encourage people at high risk for gastrointestinal cancer to get screened. It compares different methods to see which works best, helping catch cancer early when it's easier to treat.

Mosapride injection for bowel recovery after surgery

This trial tests an injectable medicine, mosapride citrate, to help the gut start working again after laparoscopic intestinal surgery. It may reduce bloating, pain, and time to first bowel movement.