Glibenclamide for nerve pain in multiple sclerosis
Part of Brain & nervous system, Immune system & allergy, Pain clinical trials.
This trial tests a drug called glibenclamide, commonly used for diabetes, to see if it can reduce nerve pain in people with multiple sclerosis. If you join, you will receive the drug or a placebo (inactive treatment) and your pain levels will be monitored.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have a confirmed diagnosis of multiple sclerosis.
- You experience significant nerve-related pain (as measured by a specific pain questionnaire).
- You do not have severe kidney or liver disease.
- You do not have type 2 diabetes requiring medication, or a history of dangerous low blood sugar.
- You are not allergic to sulfa drugs, lack G6PD enzyme, and are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests an investigational drug called crisugabalin, which may help reduce nerve pain caused by NMOSD. If you join, you will receive either the drug or a placebo (a pill with no active medicine) to see how well it works.
This trial tests an extended-release version of pregabalin (a pain medication) for people with long-term nerve pain caused by diabetes or shingles. It aims to see if this once-daily pill can reduce pain with fewer side effects.
This Phase 3 study tests Praga formulation to see if it safely reduces nerve pain caused by diabetes. You may qualify if you’re an adult with painful diabetic neuropathy and have certain symptom and pain scores on questionnaires.
This study tests whether a smartphone app can help people with multiple sclerosis manage nerve pain and improve their quality of life. If you have MS and nerve pain, you may be able to join and use the app as part of the study.
This study tests whether the medicine piracetam can help with nerve pain or symptoms caused by diabetes (diabetic neuropathy). If it works, it may offer a new way to ease discomfort and improve your daily life.
This trial tests whether the drug trimetazidine can improve nerve damage symptoms in people with type 2 diabetes and diabetic neuropathy. It also looks at how the drug affects a substance in the blood called endothelin-1, which may be involved in nerve damage.
Hear when a new Multiple sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.