Clin2
NCT07248020Possibly a fitNot yet recruiting

Curcumin with standard therapy for rectal cancer before surgery

Rectal CancerLocally Advanced Rectal CancerRadiation-Induced EnteritisRadiation ProctitisChemoradiotherapy-Related Toxicity

Treatments studied

Part of Cancer, Digestive system clinical trials.

This study tests whether adding a natural compound called curcumin to standard chemotherapy and radiation before rectal cancer surgery can help shrink the tumor more effectively. It aims to improve outcomes and includes careful monitoring of tumor tissue to understand how the treatment works.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
72 people
Ages
20 years and older
Study type
Interventional

Who can take part

  • You are at least 20 years old
  • You have rectal cancer that is within 10 cm of the anus and has not spread to distant organs
  • You are able to undergo standard chemoradiotherapy followed by surgery
  • Your overall health status is good (able to carry out daily activities)
  • You are not pregnant, breastfeeding, or planning to become pregnant during the trial
  • You do not have diabetes

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05998122Not yet recruiting· Phase 2
Chemotherapy, radiation, and immunotherapy before surgery for rectal cancer

This study tests a combination of chemotherapy, radiation, and an immunotherapy drug (called anti-PD-1) before surgery for rectal cancer that has not spread. The goal is to see if this approach can shrink or eliminate the tumor, potentially improving outcomes.

Changchun, Jilin
NCT07381400Not yet recruiting· Phase 2
Chemotherapy and immunotherapy before surgery for rectal cancer

This trial tests whether giving chemotherapy and an immunotherapy drug before surgery can help shrink rectal cancer tumors and improve outcomes. It is for patients whose tumors are not caused by a specific genetic mismatch repair problem.

NCT06637462Recruiting
Studying standard treatment response before rectal cancer surgery

This study looks at how rectal cancer responds to the usual chemotherapy and radiation given before surgery. It aims to learn if certain molecular features of your tumor can predict how well it responds to treatment.

Middletown, New Jersey
NCT03975049Not yet recruiting· Phase 3
Combination chemotherapy before surgery for locally advanced rectal cancer

This trial compares different combinations of chemotherapy drugs given before surgery to the standard approach of chemoradiation (chemotherapy plus radiation) for rectal cancer that has not spread. The goal is to see if the drug combinations are more effective at shrinking tumors and improving outcomes.

NCT06894797Recruiting
Chemo and radiation before and after surgery for rectal cancer

This study tests a sequence of chemotherapy and radiation before and after surgery for rectal cancer. It compares giving more chemo between the end of radiation and surgery (consolidation) versus giving some chemo before radiation starts (induction). The goal is to see which order works better.

Beijing
NCT06832917Not yet recruiting· Phase 3
Short-course radiation plus immunotherapy and chemo before surgery for rectal cancer

This trial tests a new treatment sequence for locally advanced rectal cancer: a short course of radiation followed by a combination of immunotherapy (cadonilimab) and chemotherapy (mFOLFOX6) before surgery. The goal is to shrink the tumor more effectively and potentially improve outcomes.

Hear when a new Rectal Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.