Testing EA5 in adults with paroxysmal nocturnal hemoglobinuria (PNH)
Part of Blood & lymphatic clinical trials.
This clinical trial tests an investigational drug called EA5 for people with PNH, a rare blood disease where red blood cells break down too quickly. It is for adults who either have never taken a complement inhibitor or stopped taking one recently, and who still have signs or symptoms of PNH.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and weigh between 88 and 220 pounds.
- You have been diagnosed with PNH and have a certain level of disease activity (your LDH is at least 1.5 times the normal limit).
- You have had PNH symptoms (like tiredness, dark urine, belly pain, trouble breathing, low red blood cells, or blood clots) or needed a blood transfusion in the last 3 months.
- You have not had a bone marrow transplant, do not have serious infections or a weak immune system, and are up-to-date on certain vaccines (meningococcal and pneumococcal).
- You are willing to follow contraception guidelines and other study rules.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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