Clinical trials
Mild Autonomous Cortisol Secretion (MACS) clinical trials
Below are recruiting mild autonomous cortisol secretion (macs) clinical trials, each written for real people, not researchers. We’re tracking 9 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07573163RecruitingPhase 2
Tirzepatide after adrenal surgery for mild cortisol condition
This trial tests if tirzepatide can help with weight and blood pressure after you have surgery to remove an adrenal gland that's making too much cortisol. It may be a good option if you still have health issues like high blood pressure or obesity after surgery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07649317RecruitingPhase 1
Ketoconazole effects on cortisol rhythms in mild adrenal hormone changes
This study tests whether the drug ketoconazole can safely help regulate daily cortisol patterns in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands make too much cortisol. It will compare how patients with MACS and healthy volunteers respond to the medication.
Bethesda, MarylandAges 18–100 - NCT06344143Recruiting
Detecting mild hormone overproduction from adrenal tumors
This study looks for a mild form of hormone overproduction (called autonomous cortisol secretion) in people who have a benign growth on their adrenal gland. You will undergo a blood test to measure how well your body suppresses cortisol after taking a single dose of dexamethasone.
Cleveland, OhioAges 18 years+ - NCT07387419Recruiting
Steroid Hormone Rhythms in Adrenal Nodules
This study looks at how your body's natural steroid rhythms change when you have adrenal nodules. It compares people with non-secreting nodules to those with a mild hormone excess (MACS) to see if there are differences in daily cortisol patterns.
PessacAges 18 years+ - NCT07268222RecruitingPhase 4
Comparing two drugs for metabolic autonomous cortisol secretion
This trial tests whether metyrapone or osilodrostat works better for people with MACS, a condition where the adrenal glands produce too much cortisol on their own. The goal is to help you and your doctor choose the best treatment.
AthensAges 18 years+ - NCT04543253Recruiting
Recovery study after Cushing surgery for cortisol excess
This study looks at how people recover after surgery to treat Cushing syndrome and mild cortisol overproduction. It may help doctors understand what recovery looks like and how treatment affects cortisol levels and symptoms.
Rochester, MinnesotaAges 18 years+ - NCT07104812RecruitingPhase 2
Testing low-dose osilodrostat for mild cortisol excess
This study tests whether a low dose of the drug osilodrostat can help people with mild cortisol excess (MACS) caused by benign adrenal tumors. It may improve related health problems like high blood pressure, diabetes, or bone thinning.
Rochester, MinnesotaAges 18 years+ - NCT07247058RecruitingPhase 4
Testing Isturisa for mild cortisol excess from adrenal tumors
This study tests whether a drug called Isturisa (osilodrostat) can safely lower mild cortisol excess in people with adrenal tumors. It aims to help patients avoid the long-term effects of too much cortisol.
Baltimore, MarylandAges 18 years+ - NCT07361874Recruiting
Adrenal surgery vs semaglutide for mild cortisol excess
This study tests whether removing a small adrenal tumor or taking a diabetes/weight-loss medication (semaglutide) works better to improve health in people with mild hormone problems. It may help if you have an adrenal nodule causing slight cortisol overproduction or if you have obesity and related conditions.
Dallas, TexasAges 18 years+
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Common questions
- Are there clinical trials for mild autonomous cortisol secretion (macs)?
- Yes. Clin2 currently lists 9 recruiting mild autonomous cortisol secretion (macs) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mild autonomous cortisol secretion (macs) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mild autonomous cortisol secretion (macs) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.