Adrenal surgery vs semaglutide for mild cortisol excess
Part of Cancer, Hormones & metabolism clinical trials.
This study tests whether removing a small adrenal tumor or taking a diabetes/weight-loss medication (semaglutide) works better to improve health in people with mild hormone problems. It may help if you have an adrenal nodule causing slight cortisol overproduction or if you have obesity and related conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have a small adrenal growth (adenoma) that causes mild cortisol excess, or you have obesity with at least two heart/metabolic problems (like high blood pressure or diabetes)
- If you have the adrenal growth, you are willing to delay surgery for 6 months if assigned to the medication group
- You have not used semaglutide or similar drugs in the last 90 days
- Your weight has been stable (no more than about 11 pounds change) in the last 3 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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