Vancomycin for knee replacement surgery
Treatments studied
Part of Bones, joints & muscles, Infections, Injuries & trauma clinical trials.
This trial is testing the antibiotic vancomycin to prevent infections after total knee replacement. It may help if you are having your first knee replacement and are not severely overweight or diabetic.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and being treated at UC San Diego Health
- You are having your first total knee replacement on one knee
- You have not had knee surgery before (except minor arthroscopy)
- Your body mass index (BMI) is 35 or less
- You are not allergic to vancomycin, cefepime, or cefazolin
- You are not diabetic with an A1c over 7.5% (unless controlled)
- You are not immunocompromised (no HIV, hepatitis C, end-stage kidney disease, organ transplant, recent chemotherapy, or immune-suppressing drugs)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests giving the antibiotic vancomycin directly into the bone during knee replacement surgery to see if it helps prevent infections. If you are scheduled for a first-time knee replacement, this could help lower your risk of infection after surgery.
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
This study tests whether putting vancomycin powder in the surgical wound during hip or knee replacement surgery reduces the risk of infection. It is for adults having their first replacement due to osteoarthritis.
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
This trial tests whether adding antibiotics to the bone graft used during hip replacement surgery can lower the risk of infection. It may help people who need a bone graft as part of their hip replacement.
This study looks at ways to lower the risk of infection after knee replacement surgery (with or without vancomycin, an antibiotic). If you’re a good candidate, you may receive an approach aimed at preventing post-surgery infections and related complications.
Hear when a new Total Knee Arthroplasty trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.