Antibiotics via bone injection for knee replacement
Part of Bones, joints & muscles clinical trials.
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled to have a total knee replacement (first time on that knee).
- You are 18 years or older.
- You do not have an allergy or other reason you cannot receive cefazolin or vancomycin.
- Your body mass index (BMI) is 40 or less.
- Your diabetes is well-controlled (A1c level 7.5% or lower).
- You have not received vancomycin or cefazolin by IV in the 7 days before surgery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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