Antibiotic injection into ankle bone for knee replacement revision
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study compares two ways of giving antibiotics before a second knee replacement surgery. It tests if injecting antibiotics into the ankle bone is as good as giving them through an IV.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are having a revision (second) total knee replacement where the old implant blocks a common injection site in the shin bone.
- You can understand the study and give your permission (informed consent).
- You are 18 years or older.
- You are not allergic to vancomycin, cefepime, ancef, or other similar antibiotics used before surgery.
- You have not received IV vancomycin in the 7 days before your planned surgery.
- There is no hardware or condition that would prevent an injection into your inner ankle bone (medial malleolus).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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