Antibiotic through ankle bone versus IV for revision knee replacement
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study compares two ways of giving a common antibiotic before a revision knee replacement: either directly into the bone at the ankle or through an IV. The goal is to see if the bone injection works better at preventing infection, which might lead to better outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for a revision total knee replacement (a second or later surgery).
- You are older than 18 years.
- You can understand the study and give informed consent.
- You are not allergic to the antibiotics used in the study (vancomycin, cefepime, or cefazolin).
- You have not received intravenous vancomycin within 7 days before your surgery.
- The inside of your ankle (medial malleolus) must be a usable site for the injection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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