Clin2
NCT06884748Possibly a fitNot yet recruiting

Adding bile acid treatment to prevent C. diff from returning

Clostridioides Difficile Infection

Part of Infections clinical trials.

This study tests whether adding a common bile acid (ursodeoxycholic acid) to your regular C. diff treatment can help stop the infection from coming back. The goal is to see if this extra medicine reduces the chance of recurrence.

Summary written for real people, not researchers, by Clin2.

Phase
Early Phase 1
Enrollment
30 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older and have tested positive for a C. diff infection.
  • You have at least one factor that raises your risk of the infection coming back (like being older, having been in the hospital, or taking antibiotics).
  • You are currently taking or about to start a standard C. diff medicine (Flagyl, Vancomycin, or Dificid).
  • You are expected to live at least 6 more months and do not have severe colitis or an intestinal blockage.
  • You do not have severe liver disease, and you are not pregnant or breastfeeding.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07613645Recruiting
Lifestyle changes to prevent recurring C. difficile infection

This study tests whether specific lifestyle changes during treatment for C. difficile infection (a serious gut bacteria infection) can help prevent it from coming back. You'll receive standard antibiotic treatment and follow a controlled diet while researchers track your recovery.

Ann Arbor, Michigan
NCT07285213Recruiting· Phase 2
Preventing C. diff return with an antibody

This study tests a new antibody (AZD5148) to prevent C. diff infection from coming back. If you have a current C. diff infection and are being treated with antibiotics, you may be able to join.

Phoenix, Arizona
NCT07120490Not yet recruiting
Comparing treatments for C. diff infection to stop it from returning

This trial compares three treatments for a severe diarrhea infection called C. diff: a fecal transplant (putting healthy donor stool into your gut), a newer antibiotic called fidaxomicin, and an older antibiotic called vancomycin. The goal is to see which works best and prevents the infection from coming back.

NCT04305769Recruiting· Phase 2
Alanyl-glutamine to help treat C. difficile diarrhea

This study tests whether the supplement alanyl-glutamine, given along with standard treatment, can improve outcomes for adults being treated for C. difficile infection (a cause of diarrhea). It may help the body recover better after antibiotics that usually treat C. difficile.

Charlottesville, Virginia
NCT06306014Recruiting· Phase 1/Phase 2
Study of a new therapy to prevent C. diff recurrence

This study tests a new live bacteria product (EXL01) given with vancomycin to prevent C. diff from coming back. It is for people who have already had C. diff two or more times and are at high risk of another infection.

Annecy
NCT06237452Recruiting· Phase 3
VE303 to prevent repeat C. diff infections

This trial tests a new medicine called VE303, a live bacterial therapy, to prevent C. diff infections from coming back. It is for people who have had C. diff at least once in the last 6 months, or who are at high risk for a repeat infection due to age or other health problems.

Huntsville, Alabama

Hear when a new Clostridioides Difficile Infection trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.