Blood test study for severe leg artery disease
Part of Heart & circulation clinical trials.
This study looks at a protein on immune cells in the blood of people with advanced peripheral artery disease (narrowed leg arteries). It is a first step toward testing a new class of drugs (GLP-1 receptor agonists) to help people with severe leg circulation problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 40 years old or older
- You need a confirmed diagnosis of peripheral artery disease (PAD) — either pain when walking (intermittent claudication) or more severe symptoms like pain at rest or non-healing wounds (chronic limb-threatening ischemia)
- You cannot have diabetes (type 1 or type 2)
- You cannot be taking SGLT2 inhibitors or GLP-1 receptor agonists (medications for diabetes/weight loss)
- You must not have a serious infection, active cancer, or need dialysis for kidney failure
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at results of a minimally invasive procedure done inside blood vessels (endovascular therapy) for people with painful or worsening leg artery disease. It uses both past (retrospective) and future (prospective) patient information to better understand outcomes.
This study tests a special catheter to open blocked arteries in the thigh, knee, or lower leg. It may help improve blood flow and reduce symptoms like leg pain or wounds.
This study looks at whether giving certain blood-thinning medicines after a leg artery procedure helps prevent serious problems like heart attacks or strokes. It compares different treatment plans to see which is safer and more effective.
This study looks for markers in the blood of people with peripheral arterial disease (PAD), a condition where leg arteries narrow and reduce blood flow. It aims to better understand the disease and improve future diagnosis and treatment.
This study looks at how blood flows in the legs of people with peripheral artery disease (narrowed leg arteries) compared to healthy people. It uses CT scans to create 3D models, which may help doctors understand the disease better and could lead to better treatments.
This study uses ultrasound to measure blood flow in the legs of people with PAD symptoms and healthy volunteers. It aims to improve how doctors assess peripheral arterial disease without invasive tests.
Hear when a new Chronic Limb-Threatening Ischemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.