Comparing dapagliflozin versus metformin for antipsychotic weight gain
Treatments studied
Part of Mental health clinical trials.
This study compares two medicines, dapagliflozin and metformin, to see which is better at helping people who have gained weight from antipsychotic medications. Both are already approved for diabetes but may also help with weight loss.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 16 or older and have a mental health condition (like schizophrenia, bipolar disorder, or depression) for which you take antipsychotic medication.
- You have been on the same antipsychotic for at least 3 months.
- You have gained weight because of the antipsychotic — either a 7% weight gain since starting it or a BMI over 25 with weight gain linked to the medication.
- You do not have diabetes or polycystic ovary syndrome (PCOS).
- You are not currently taking metformin, dapagliflozin, or similar medicines for weight loss or diabetes.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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