Combination therapy for EGFR-mutated lung cancer with lingering ctDNA
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests if adding sacituzumab tirumotecan to osimertinib works better than osimertinib alone for advanced lung cancer that still shows cancer DNA (ctDNA) in the blood after initial osimertinib treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have advanced non-squamous non-small cell lung cancer (NSCLC) with an EGFR mutation (exon 19 deletion or L858R).
- You should have completed 3 to 5 weeks of osimertinib as your first treatment without the cancer progressing, and your ctDNA test must be positive.
- You need at least one tumor that can be measured on scans.
- You must be 18 or older and have good organ function (kidneys, liver, bone marrow).
- You cannot have had prior cancer treatment for this stage except osimertinib, and no prior TROP2- or topoisomerase I-targeted therapies.
- Women of childbearing potential and men with partners must use effective contraception during and 6 months after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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