Repeated clot-busting drug for stroke with large vessel block
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests if giving a second dose of the clot-busting drug tenecteplase can help people whose stroke symptoms don't improve after the first dose, when a large or medium artery in the brain is still blocked. It may be an option for patients who cannot have a mechanical clot removal procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You had an ischemic stroke (clot in the brain) and received standard clot-busting medicine within 4.5 hours, but your symptoms did not get much better after 1 hour
- You still have a blocked large or medium artery in the brain on imaging scan (like CTA or MRA) taken 1 hour after the first medicine, and no bleeding in the brain
- You can get the second dose of medicine within 6 hours of the stroke starting
- You have not had any bleeding problems or taken certain blood thinners recently
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if giving a second dose of a clot-busting drug (tenecteplase) helps people who had a stroke and didn't improve much after the first dose. You must receive the second dose within 4.5 hours of your stroke symptoms starting.
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