Second IV Clot-Dissolving Treatment for Major Stroke
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests giving a second dose of an IV clot-dissolving medicine (prourokinase) to patients who had a stroke from a large clot but didn't improve enough after the first dose. The goal is to see if a second dose within 6 hours of stroke onset can help more patients recover.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had a major stroke (large or medium vessel clot) and received IV prourokinase within 4.5 hours of symptom start
- Your stroke didn't improve much (or got worse) 1 hour after the first treatment, and imaging confirms the clot is still there
- You have a neurological exam score (NIHSS) of at least 4, and your brain imaging score (ASPECTS) is at least 6
- You are at least 18 years old and either having your first stroke or a past stroke with no lasting problems
- You are not scheduled for endovascular thrombectomy (mechanical clot removal) and have no blood clotting disorders
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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