Repeated clot-busting drug for stroke within 3 hours
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests if giving a second dose of a clot-busting drug (tenecteplase) helps people who had a stroke and didn't improve much after the first dose. You must receive the second dose within 4.5 hours of your stroke symptoms starting.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You had a stroke and got standard clot-busting medicine within 3 hours of symptoms starting
- Your stroke symptoms were moderate to severe (NIHSS score 4 or more) before the first treatment
- One hour after the first treatment, your symptoms didn't get much better (NIHSS improvement of 2 points or less) or they got worse, and a brain scan ruled out bleeding
- You can get the second dose of the study drug within 4.5 hours of your stroke symptoms starting
- This is your first stroke, or you had a prior stroke with no lasting major disability (mRS score 0 or 1)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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