Measuring Hsp90 in the brain with a PET scan
Part of Brain & nervous system, Hormones & metabolism, Mental health clinical trials.
This study uses a special PET scan to measure a protein called Hsp90 in the brain. It aims to understand how Hsp90 levels differ in healthy people and those with Parkinson's, Alzheimer's, or ALS, which may lead to new treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be a healthy adult aged 18-70, or have Parkinson's (age 45-85), Alzheimer's (age 45-85), or ALS (age 20-85).
- You must be able to lie still inside a PET/MRI scanner for at least 70 minutes.
- For Parkinson's, you need a diagnosis confirmed with a DaTscan. For Alzheimer's, you need a MoCA score under 26 and amyloid evidence. For ALS, you need a possible or definite diagnosis.
- You must avoid pregnancy or use highly effective birth control during and for a period after the study.
- You must not have major heart, kidney, liver disease, diabetes, or most cancers. No drug or alcohol abuse allowed.
- You must not have certain MRI contraindications like metal implants or severe claustrophobia.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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