Comparing two medicines for acidosis after heart surgery

This trial tests whether taking sodium bicarbonate tablets by mouth can help correct low bicarbonate levels in people on hemodialysis, compared to using higher bicarbonate in the dialysis fluid. It aims to find a safer and more effective way to treat metabolic acidosis, a common condition in dialysis patients.

This trial tests if giving sodium bicarbonate helps critically ill patients who have both metabolic acidosis (too much acid in the blood) and acute kidney injury (sudden kidney trouble). It aims to see if this treatment can improve outcomes.

This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.

This trial tests whether adding an “alkali” treatment (to raise low blood bicarbonate) can improve blood vessel and kidney graft function in people whose kidney transplant is about 1 year old. It may help if you have lower-than-normal bicarbonate levels while on stable transplant and blood pressure medicines.

This study tests a new non-invasive way to monitor how well oxygen is being delivered to your body during and after heart surgery. Researchers will compare this new monitoring method with standard devices that are already being used during your surgery.

This trial tests two medicines—ACT (a blood thinner) and tranexamic acid (a medicine to reduce bleeding)—to see which is better at controlling bleeding during heart surgery. It is for adults having planned heart surgery with a heart-lung machine.