Healthy bacteria transfer for confusion after liver shunt
Treatments studied
Part of Brain & nervous system, Digestive system, Hormones & metabolism clinical trials.
This study tests whether giving a fecal microbiota transplant (FMT) – putting carefully screened donor bacteria into your colon – can help prevent repeated episodes of confusion and memory problems (hepatic encephalopathy) that can happen after a liver procedure called TIPS. The goal is to improve your thinking and quality of life by restoring healthy gut bacteria.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old
- You have had a serious liver problem like bleeding from veins in your food pipe or belly swelling that did not get better with usual care
- You have had a procedure called TIPS, and then at least two episodes of confusion or memory problems in the past 6 months despite taking medications for it
- You are willing to receive a fecal microbiota transplant, which involves putting healthy donor bacteria into your gut
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if transferring healthy bacteria into your gut (fecal microbiota transplant) can help people who still get confusion episodes (hepatic encephalopathy) even after a TIPS procedure and while on standard medications like lactulose and rifaximin.
This study tests whether delivering healthy bacteria from a donor's stool (called a microbiota transplant) through a capsule can help people with cirrhosis and a history of hepatic encephalopathy. The goal is to improve brain function and reduce the risk of further confusion episodes.
This trial studies whether taking rifaximin plus lactulose can prevent a brain problem called hepatic encephalopathy (confusion) after TIPS, a procedure to reduce pressure in the liver. It may help people who are having TIPS planned and are at risk of this complication.
This study tests if giving a fecal transplant (a procedure that transfers healthy bacteria from a donor's stool into your gut) before a liver transplant can lower the risk of serious infections after the surgery. It might help strengthen your immune system to fight off germs.
This trial studies whether fecal microbiota transplantation (FMT)—a medical procedure using stool from a screened donor to restore gut bacteria—can improve safety and outcomes for people with certain bowel, immune, and metabolic conditions. It may help if your symptoms are thought to be related to an unhealthy gut microbiome, though eligibility is broad and depends on specific safety factors.
This study tests a procedure to narrow a stent in the liver to reduce episodes of confusion caused by toxins reaching the brain. It may help people who still have frequent confusion despite standard treatments.
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