Rifaximin and lactulose to prevent confusion after TIPS
Part of Brain & nervous system, Digestive system, Hormones & metabolism clinical trials.
This trial studies whether taking rifaximin plus lactulose can prevent a brain problem called hepatic encephalopathy (confusion) after TIPS, a procedure to reduce pressure in the liver. It may help people who are having TIPS planned and are at risk of this complication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old
- You have confirmed liver scarring (cirrhosis) from biopsy, scan (like Fibroscan), or standard test results
- You are scheduled for an elective TIPS procedure for hard-to-control fluid buildup or repeat bleeding from enlarged veins (varices)
- You have risk factors such as not improving with water pills, kidney/electrolyte problems from water pills, or bleeding that endoscopic treatment and beta-blockers couldn’t control
- You have not taken rifaximin within the last 3 months and you are not using ciclosporin
- You should not have certain exclusions like planned emergency TIPS within 72 hours, non-cirrhotic portal pressure, portal vein blockage, HIV, major neurologic conditions, or be pregnant/breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if transferring healthy bacteria into your gut (fecal microbiota transplant) can help people who still get confusion episodes (hepatic encephalopathy) even after a TIPS procedure and while on standard medications like lactulose and rifaximin.
This study tests if a fecal transplant (putting healthy donor stool into your gut) can help people who keep having serious liver-related brain problems after a TIPS procedure, even with standard medicines. It might restore a healthier balance of gut bacteria.
This trial compares two treatments—BCAA supplements and rifaximin—to see which is better at preventing another episode of confusion or coma in people with cirrhosis who have already had one. If you qualify, you would receive one of these treatments for several months.
This Phase 3 trial tests whether nitazoxanide can help stop hepatic encephalopathy (a “liver-to-brain” confusion problem) from coming back. It’s for adults with cirrhosis who have had at least one past episode, aiming to improve safety and prevent recurrence.
This pilot study is testing a new way to guide a TIPS procedure using a special fiber-optic navigation system, which may make the shunt placement more precise for patients with serious liver problems.
This study is testing whether a special type of starch (resistant potato starch) can help people with cirrhosis who have had episodes of confusion from liver problems. It may help by changing the bacteria in your gut, which could reduce the risk of future confusion episodes.
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