Apixaban for late portal vein clot after spleen surgery
Treatments studied
Part of Digestive system clinical trials.
This trial tests if apixaban, a blood thinner, is more effective than aspirin at treating blood clots in the portal vein that form more than a year after laparoscopic spleen removal in people with cirrhosis and an enlarged spleen.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with cirrhosis (scarring of the liver) from any cause
- Had an enlarged spleen with low blood counts due to the spleen
- Had no portal vein clot before or within a year after your laparoscopic spleen removal at the study center
- Developed a portal vein clot more than 12 months after that surgery
- Not taking blood thinners or antiplatelet drugs (like oral contraceptives or aspirin) at study start
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is testing whether a blood thinner called apixaban can treat a blood clot in the main vein to the liver (portal vein) that appeared more than a year after spleen surgery in people with cirrhosis. It compares apixaban to a low-dose aspirin to see if one works better with fewer side effects.
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