New Blood Thinner for Bleeding Veins in Liver Disease
Treatments studied
Part of Blood & lymphatic, Digestive system clinical trials.
This trial tests whether a newer type of blood thinner can safely prevent dangerous bleeding from enlarged veins in the food pipe (esophagus) in people with liver cirrhosis who also have blood clots in the portal vein. The goal is to reduce the risk of life-threatening bleeding while managing the clot.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have liver cirrhosis confirmed by imaging and enlarged veins in your esophagus or stomach
- You have had at least one episode of bleeding from these enlarged veins in the past
- You have a blood clot in your portal vein (a major vein in the liver) with certain blood markers showing increased clotting
- You recently had an endoscopy (camera down the throat) that showed high risk of rebleeding, and you received treatment to prevent it
- You have not previously taken blood thinners like warfarin, aspirin, or heparin
- You are willing to sign a consent form and follow the study protocol
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a blood thinner called apixaban can safely prevent dangerous bleeding in people with cirrhosis (liver scarring) who have portal hypertension (high blood pressure in veins leading to the liver). The goal is to see if it reduces bleeding risk without causing excessive bleeding.
This trial compares two blood-thinning medications, dabigatran (a pill) and enoxaparin (a shot), to see which works better and is safer for people with cirrhosis who have a blood clot in the portal vein (the main vein to the liver). It may help prevent the clot from getting worse or causing complications.
This study tests whether blood thinners (anticoagulants) are safe and effective for people with cirrhosis and a blood clot in the portal vein. It may also include people with liver cancer (HCC).
This trial tests whether placing a small tube (TIPS) at the time of variceal bleeding can prevent future bleeding in people with cirrhosis and a large clot in the liver's main vein. It aims to see if early TIPS treatment is better than standard care.
This study tracks people with liver cirrhosis to see how often portal vein thrombosis (a blood clot in the main vein to the liver) occurs and how it can be treated with blood thinners. It aims to improve care for those at risk of these clots.
This early study tests whether the blood thinner pills rivaroxaban and apixaban can be used safely in people with liver cirrhosis that is not too severe. It may help doctors understand the safest way to prevent or treat blood clots in this group.
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