Sildenafil for severe pulmonary hypertension from rheumatic valve disease
Treatments studied
Part of Heart & circulation, Lungs & breathing clinical trials.
This trial tests if sildenafil can help people with severe pulmonary hypertension caused by rheumatic valvular heart disease. It aims to see if the drug improves symptoms and heart function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with rheumatic valvular heart disease (a condition where the heart valves are damaged by a prior strep infection).
- You are 18 to 80 years old.
- You have severe pulmonary hypertension (high blood pressure in the lungs).
- You are not planning to have heart valve surgery in the next 6 weeks.
- You do not have uncontrolled high blood pressure (above 170/110), low blood pressure (below 90/50), or unstable heart conditions.
- You have not had a stroke or heart attack in the last 6 months, and you do not take nitrates (medications for chest pain).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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