CART123 cells with or without ruxolitinib for AML
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new type of immune cell therapy (CART123) alone or with a drug called ruxolitinib for children and young adults with AML that has come back or not responded to standard treatment. The goal is to see if this combination can help destroy leukemia cells.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 1 and 29 years old (special rules for children under 12 in one group).
- Your AML must have returned after treatment or not responded to chemotherapy.
- You need to have a stem cell donor ready in case a transplant is needed after the study treatment.
- Your heart, lungs, liver, and kidneys must be working well enough (doctors will check).
- You must be able to get out of bed and take care of yourself most of the day.
- You cannot have active hepatitis B, C, HIV, or uncontrolled infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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