Preventing pouchitis after ulcerative colitis surgery
Part of Digestive system clinical trials.
This study tests whether a common anti-inflammatory medicine, called 5-ASA, can help prevent pouchitis (an inflammation of the surgically created pouch) in people with ulcerative colitis who have had restorative surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult diagnosed with ulcerative colitis
- You are scheduled to have J-pouch surgery (also known as ileal pouch-anal anastomosis) to reconstruct your bowel
- You do not have primary sclerosing cholangitis (PSC), a liver condition often associated with inflammatory bowel disease
- You have no known allergy or intolerance to 5-ASA medications (e.g., mesalamine, sulfasalazine)
- You are treated at one of the four Swedish medical centers that are part of this study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This study tests whether adding a medication called guselkumab to antibiotics can help people with chronic or recurring pouchitis, a condition that causes inflammation in the J-pouch after ulcerative colitis surgery. Participants will take antibiotics for the first 4 weeks and guselkumab as an injection over the course of the trial.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This study tests an oral treatment made from bacteria-killing viruses (phages) for pouchitis, a common complication after surgery for ulcerative colitis. The goal is to see if it safely reduces inflammation and symptoms in the pouch.
This trial tests whether the antibiotic rifaximin can prevent pouchitis from coming back after a first episode. It is for people who had ulcerative colitis, have a J-pouch, and developed pouchitis within the first year after their final surgery.
This study looks at how tryptophan, an amino acid found in foods like turkey and milk, might affect the treatment of pouchitis, which is inflammation of the pouch created after ulcerative colitis surgery. It aims to see if adding tryptophan to standard treatment with antibiotics and probiotics could help.
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