Metoprolol for heart failure: genes and drug response
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests how the drug metoprolol works in people with heart failure and reduced pumping function. It looks at whether your genetic makeup affects how the drug is processed and how well it helps your heart.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have heart failure with reduced ejection fraction (weakened heart pumping).
- You have not taken a beta-blocker (like metoprolol) in the past 3 to 6 months, or only a low dose.
- You have genetic test results already available, or are willing to give a DNA sample.
- You are white (needed for the genetic scoring).
- You are on a stable dose of certain heart medications (like ACE inhibitors or ARBs) for at least 4 weeks.
- You are not pregnant, and if you could become pregnant, you agree to use effective birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether a genetic test can help doctors choose the best beta blocker for people with heart failure who have mildly reduced pumping function. It aims to improve treatment by matching the drug to your genetic profile.
This study tests an experimental drug called LY3971297 to see if it can help people with chronic heart failure. It aims to find out if the drug is safe and if it improves heart function.
This trial tests whether a low dose of metoprolol (a beta-blocker) is safe and helpful for people who have both heart failure with reduced pumping ability and COPD. The goal is to see if it can improve heart function without worsening breathing problems.
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This study looks at different types of heart failure to better understand how they progress. It uses genetic information and clinical tests. The goal is to find more precise ways to predict outcomes and personalize treatment.
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