Combination drug trial for relapsed brain lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests three drugs together—pomalidomide, an anti-PD-1 antibody, and selinexor—to treat primary central nervous system lymphoma (a blood cancer in the brain) that has returned after previous treatment. The goal is to see if this combination can shrink the cancer and help patients live longer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with primary central nervous system diffuse large B-cell lymphoma (PCNSL-DLBCL), confirmed by biopsy.
- Your cancer has come back or stopped responding to previous treatment with high-dose methotrexate and/or BTK inhibitors.
- You are between 18 and 75 years old and expected to survive at least 3 months.
- Your blood cell counts, kidney function, and liver function meet minimum safe levels for the study drugs.
- You are not pregnant, breastfeeding, or unwilling to use effective birth control if you could become pregnant.
- You do not have active infections, HIV, autoimmune diseases, or severe neurological conditions like epilepsy or dementia.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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