Second dose of tenecteplase for stroke not responding to first
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial is testing whether a second dose of a clot-busting drug called tenecteplase can help people who are having a stroke and didn't get better after the first dose. The goal is to see if the extra dose is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have symptoms of a stroke (like weakness, trouble speaking, or vision loss).
- You are between 18 and 80 years old.
- It has been less than 3 hours since your symptoms started for the first dose, and less than 4.5 hours for the second dose.
- A CT scan shows no bleeding in the brain and a certain score (ASPECTS > 6).
- You do not have a large vessel blockage that requires a clot removal procedure (endovascular therapy) before the second dose.
- You are not on blood thinners (like warfarin, Xarelto, Eliquis, or Pradaxa) in the last 48 hours, or more than one antiplatelet (like aspirin and clopidogrel) in the last 48 hours.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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