Closing liver shunts for repeated confusion and memory problems
Part of Brain & nervous system, Digestive system, Hormones & metabolism clinical trials.
This study tests a procedure to close abnormal blood vessels in the liver that can cause confusion and memory problems. It aims to reduce these episodes and improve quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old and have cirrhosis.
- You must have had at least 2 episodes of hepatic encephalopathy in the last 6 months, even while taking lactulose and rifaximin.
- You must be currently admitted to the hospital for this condition.
- A CT or MRI must show that you have a spontaneous portosystemic shunt.
- You must NOT have severe ascites (fluid that doesn't respond to treatment), bleeding from varices, complete blockage of the portal vein, or advanced liver cancer.
- Your platelets and blood clotting must be safe for the procedure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a procedure to narrow a stent in the liver to reduce episodes of confusion caused by toxins reaching the brain. It may help people who still have frequent confusion despite standard treatments.
This trial tests a procedure called splenic artery embolization (blocking part of the blood supply to the spleen) to reduce belly fluid buildup in people with advanced liver disease. It may help if your ascites has not improved with standard treatments and you are not a candidate for TIPS.
This study compares two ways to prevent future bleeding from enlarged veins in the esophagus or stomach in people with liver cirrhosis. One method uses a small tube (called TIPS) to reduce pressure in the liver, and the other combines a banding procedure with medication. The goal is to see which approach works better.
This study compares two procedures to treat bleeding from enlarged veins in the esophagus or stomach for people with cirrhosis and an overactive spleen. The goal is to see which approach reduces bleeding risk and improves blood counts over time.
This study tests a new way to guide a procedure called TIPS, which helps relieve pressure in the liver caused by fluid buildup or bleeding. The new guidance method may make the procedure safer or more precise.
This study tests whether giving a fecal microbiota transplant (FMT) – putting carefully screened donor bacteria into your colon – can help prevent repeated episodes of confusion and memory problems (hepatic encephalopathy) that can happen after a liver procedure called TIPS. The goal is to improve your thinking and quality of life by restoring healthy gut bacteria.
Hear when a new Hepatic Encephalopathy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.