Allopurinol as an Add-On Treatment for Depression
Treatments studied
Part of Mental health clinical trials.
This trial tests whether allopurinol, a medication typically used for gout, might help reduce depression symptoms when added to standard depression treatment. Researchers believe it may work by reducing inflammation in the brain that contributes to depression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have moderate to severe depression (confirmed by a clinical assessment)
- You do not have bipolar disorder (Type I or Type II)
- You do not have an eating disorder
- You have healthy kidney function
- You have no serious heart or cardiovascular problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a combination of cognitive training (brain exercises) and a medication (guanfacine or sertraline) can improve thinking skills in people with depression. It involves MRI scans and computer tasks to understand how your brain responds.
This Phase 2 trial tests OSU6162 added to an SSRI or SNRI in people whose major depression did not improve enough after trying specific antidepressants for at least 6 weeks. It may help reduce depression symptoms when standard treatments haven’t worked well.
This trial tests if adding a statin (a cholesterol-lowering medicine) to your current depression treatment improves symptoms. It is for adults aged 20 to 45 with mild to moderate depression who are not already taking a statin.
This study tests if adding roflumilast, a medicine that reduces inflammation, can help people with major depression feel better when taken with their current antidepressant. It is for adults with moderate to severe depression.
This trial studies a natural brain chemical called allopregnanolone in women with premenstrual dysphoric disorder (PMDD) that responds to SSRI antidepressants. It aims to understand how the brain adapts and whether this treatment could help.
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.