PEEP levels in ARDS based on lung response
Part of Lungs & breathing clinical trials.
This study tests whether adjusting ventilator settings based on how well your lungs respond can improve oxygen and reduce damage in patients with moderate to severe ARDS, within the first 36 hours of diagnosis.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have moderate or severe ARDS, diagnosed within the last day and a half (36 hours).
- Your blood oxygen level is 200 or less on a standard ventilator test, with at least 5 cmH2O of PEEP.
- Your blood pressure is stable, with no need for high doses of a medicine called norepinephrine (less than 0.5 mcg/kg/min).
- No air leaks in your lungs, like a collapsed lung or air in the chest cavity.
- No problems that prevent placement of a small tube in your esophagus to measure pressure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests two different methods to help doctors adjust breathing machine settings for patients with severe lung injury. The trial compares gentle chest/belly compressions with a special imaging technique to find the safest pressure levels.
This trial compares two levels of positive end-expiratory pressure (PEEP) in patients on a breathing machine. It looks at how these pressures affect diaphragm function, how well the lungs work, and how efficiently you breathe.
This trial tests a special monitoring technique called EIT (electrical impedance tomography) to help doctors set the best breathing machine pressure for people with ARDS. It may help improve oxygen levels and protect the lungs.
This trial uses a special lung imaging technique (EIT) to guide ventilator settings for people with ARDS. It may help improve breathing support and reduce lung injury.
This study tests two methods of adjusting a ventilator to see which one may better protect the lungs of patients with ARDS. It will help doctors learn how to set the machine to reduce strain on the lungs.
This study compares different ways of setting the positive end-expiratory pressure (PEEP – the pressure that helps keep your lungs open on the ventilator) to find the best approach for people with moderate-to-severe ARDS. It uses existing sensors – an esophageal pressure probe and a chest impedance belt – to guide the settings, which may improve breathing support and recovery.
Hear when a new ARDS (Acute Respiratory Distress Syndrome) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.