Clot-busting drug after successful clot removal for stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether giving a clot-busting drug (alteplase) directly into the brain artery after a successful clot removal improves recovery in people with severe stroke. It is for patients who have had a thrombectomy and still have a large blocked artery in the front of the brain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You had a stroke caused by a blockage in a large artery in the front part of your brain.
- You had a clot-removal procedure (thrombectomy) that reopened the artery successfully.
- The time from when you were last seen normal to starting the study is within 24 hours.
- Your stroke symptoms are moderate to severe (NIHSS score 6–25) and brain imaging shows a certain amount of salvageable brain tissue.
- You have no major bleeding risks or other medical conditions that would make the study treatment unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
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