Pridopidine to slow Huntington's disease progression
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Mental health clinical trials.
This study tests whether a medication called pridopidine can help slow the progression of Huntington's disease symptoms in adults. Huntington's is a genetic disorder affecting movement, mood, and thinking, and this trial aims to see if pridopidine improves daily functioning and quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed Huntington's disease diagnosis with the genetic mutation (≥40 CAG repeats) and clear motor symptoms
- You are at least 21 years old and had symptom onset at age 21 or later
- You still have significant functional ability (score of 7 or higher on a standard scale)
- You have moderate motor symptoms (a score of 20 or higher on movement testing)
- You have not taken certain movement-disorder medications (VMAT2 inhibitors or antipsychotics) for at least 6 months
- You don't have serious heart conditions, recent seizures, or other major medical or psychiatric problems that could interfere with the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a gene therapy called SPK-10001 for people with early-stage Huntington's disease. It aims to slow the progression of symptoms by targeting the genetic cause of the disease.
This trial tests a new drug called SKY-0515 in people with Huntington's disease. The goal is to see if it can safely improve symptoms or slow the disease down.
This study uses special brain imaging and memory/thinking tests to find early “markers” that can predict how Huntington’s disease will progress over time. You may qualify as someone with early-stage Huntington’s or as a healthy control, if you meet specific safety and scoring requirements.
This Phase 2 study tests whether taking thiamine and biotin together can improve symptoms in people with Huntington’s disease. It looks especially at people with confirmed genetic Huntington’s disease and certain types of movement and/or mood symptoms.
This trial tests if a vitamin B3-like supplement, nicotinamide riboside, can help people with early to mid-stage Huntington's disease. You will be randomly assigned to take the supplement or a placebo to see if it slows the disease.
This study tests new ways to measure thinking and memory skills in people with Huntington's disease. It aims to find better tools for tracking the disease and could help you understand your cognitive changes.
Hear when a new Huntington Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.