Clinical trials
Huntington Disease clinical trials
Below are recruiting huntington disease clinical trials, each written for real people, not researchers. We’re tracking 41 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07253038Recruiting
Testing social skills in Huntington's disease
This study tests three different ways to measure social skills (like understanding emotions or reading social cues) in people with Huntington's disease. The goal is to find which test works best for future research and care.
LundAges 18–75 - NCT07378644RecruitingPhase 2/Phase 3
Testing SKY-0515 for Huntington's disease
This trial tests a new drug called SKY-0515 in people with Huntington's disease. The goal is to see if it can safely improve symptoms or slow the disease down.
Englewood, ColoradoAges 25 years+ - NCT07010705Recruiting
Digital measures for Huntington's disease trials
This study uses smartphone and wearable sensors to track movement and thinking in people with Huntington's disease. It aims to find better ways to measure how the disease progresses in clinical trials.
Rochester, New YorkAges 25–65 - NCT07326709RecruitingPhase 3
Votoplam for Huntington's disease: a Phase 3 study
This study tests an investigational drug called Votoplam for people with Huntington's disease. It aims to see if the drug can slow progression of symptoms like movement and thinking problems.
La Jolla, CaliforniaAges 21–70 - NCT07609108RecruitingPhase 3
Pridopidine to slow Huntington's disease progression
This study tests whether a medication called pridopidine can help slow the progression of Huntington's disease symptoms in adults. Huntington's is a genetic disorder affecting movement, mood, and thinking, and this trial aims to see if pridopidine improves daily functioning and quality of life.
Birmingham, AlabamaAges 23–65 - NCT04012411Recruiting
Testing brain fluid biomarkers in Huntington’s disease
This study looks at specific “biomarkers” (measurable signs) found in cerebrospinal fluid, to better understand Huntington’s disease. The results may help researchers track the disease and improve future tests or treatments.
MontpellierAges 18 years+ - NCT04478734RecruitingPhase 2
Thiamine plus biotin for Huntington’s disease symptoms
This Phase 2 study tests whether taking thiamine and biotin together can improve symptoms in people with Huntington’s disease. It looks especially at people with confirmed genetic Huntington’s disease and certain types of movement and/or mood symptoms.
San Sebastián, San SebastianAges 18 years+ - NCT05326451Recruiting
At-home brain stimulation for Huntington’s behavior and thinking symptoms
This trial tests an at-home, noninvasive brain stimulation treatment to help with behavioral and cognitive (thinking) symptoms in people with Huntington’s disease. You and a caregiver work together during sessions and questionnaires to see if symptoms improve and stay stable.
Houston, TexasAges 18–80 - NCT06546488Recruiting
Cognitive Testing for Huntington's Disease Study
This study tests new ways to measure thinking and memory skills in people with Huntington's disease. It aims to find better tools for tracking the disease and could help you understand your cognitive changes.
Columbus, OhioAges 30–65 - NCT06774443Recruiting
Testing social thinking in Huntington's disease
This trial uses a hinting task to study how people with Huntington's disease understand indirect requests. It may help researchers learn more about social thinking in this condition.
Groningen, Provincie GroningenAges 18–74 - NCT06826612RecruitingPhase 1/Phase 2
Gene therapy trial for early Huntington's disease
This trial tests a gene therapy called SPK-10001 for people with early-stage Huntington's disease. It aims to slow the progression of symptoms by targeting the genetic cause of the disease.
Boston, MassachusettsAges 25–65 - NCT06843252Recruiting
Home-based brain stimulation for Huntington's disease symptoms
This study tests whether a gentle brain stimulation device (tDCS) used at home can help improve thinking and behavior in people with Huntington's disease. A caregiver is needed to be present during treatment and help with questionnaires.
San Antonio, TexasAges 18–85 - NCT06853743RecruitingPhase 2
Study of nicotinamide riboside for Huntington's disease
This trial tests if a vitamin B3-like supplement, nicotinamide riboside, can help people with early to mid-stage Huntington's disease. You will be randomly assigned to take the supplement or a placebo to see if it slows the disease.
OsloAges 18–80 - NCT07451613RecruitingPhase 1/Phase 2
Stem cell therapy trial for Huntington's disease
This trial tests whether human neural stem cells are safe and tolerable for people with Huntington's disease. It involves a neurosurgical procedure to inject the cells into the brain, along with MRI scans and other monitoring.
Irvine, CaliforniaAges 18–65 - NCT07513844Recruiting
Ultrasound Treatment for Huntington's Disease Movement Symptoms
This trial tests a new focused ultrasound technique aimed at reducing involuntary movements (chorea) in people with Huntington's disease. The treatment targets a specific brain region and may help improve movement control and quality of life.
Fuzhou, FujianAges 18–75 - NCT07246941RecruitingPhase 1
Safety of RG6496 in Huntington's disease
This is an early-phase study testing a new drug (RG6496) for people with Huntington's disease. The study will check the drug's safety and how the body processes it, and it requires two doses given about 6 months apart.
Ciudad Autonoma Bs AsAges 25–65 - NCT06828471Recruiting
Social skills training for Huntington's disease
This study tests a social cognition training program for people with Huntington's disease and their caregivers. It aims to help improve social understanding and interactions.
Chicago, IllinoisAges 18–65 - NCT07537075Enrolling by invitationPhase 2/Phase 3
Continuing SKY-0515 treatment for Huntington's disease
This is a follow-up study for people with Huntington's disease who already completed an earlier SKY-0515 trial and tolerated it well. Researchers want to see how safe and effective the drug continues to be with longer-term use.
New Lambton Heights, New South WalesAges 25 years+ - NCT05808153Recruiting
Brain scans and thinking tests to track Huntington’s progression
This study uses special brain imaging and memory/thinking tests to find early “markers” that can predict how Huntington’s disease will progress over time. You may qualify as someone with early-stage Huntington’s or as a healthy control, if you meet specific safety and scoring requirements.
Créteil, Île-de-France RegionAges 18–65 - NCT06585449RecruitingPhase 1
Study of ALN-HTT02 for Huntington's disease
This trial tests an experimental drug called ALN-HTT02 for people with Huntington's disease. The goal is to see if it can help manage symptoms. Participants must have stage 2 or early stage 3 Huntington's disease.
EdmontonAges 25–70 - NCT02855476Recruiting
Collecting spinal fluid samples to help Huntington’s research
This study gathers small samples of spinal fluid from people affected by Huntington’s disease. Researchers use these samples to better understand the disease and support future treatments. If you join, you’ll need to follow their sample and visit schedule.
Englewood, ColoradoAges 11–75 - NCT07536061RecruitingPhase 1
Testing SRP-1005 in early-stage Huntington's disease
This first-in-human study tests whether SRP-1005, a new drug, is safe and tolerable in people with early Huntington's disease. The drug is designed to reduce levels of a harmful protein in the brain that causes Huntington's symptoms.
AucklandAges 21–70 - NCT06807892Recruiting
Comparing exercise games for thinking and movement in Huntington's disease
This study tests two different types of video game-based exercises to see which one better helps thinking skills, movement, and mood in people with Huntington's disease. You would play these games as part of your care, and the results may guide future therapy choices.
AngersAges 18 years+ - NCT01574053Recruiting
Global Huntington’s disease registry for gene carriers and controls
This study builds a global record of people who carry the Huntington’s (HD) gene change and people who do not. By comparing them over time, researchers hope to better understand how HD begins and progresses.
Birmingham, AlabamaAges 18 years+
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Huntington Disease trials by city
Studies with a site in or near these metro areas.
Huntington Disease trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for huntington disease?
- Yes. Clin2 currently lists 41 recruiting huntington disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a huntington disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a huntington disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.