PFO Closure to Reduce Migraine Headaches
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This trial tests whether closing a small heart opening (called a patent foramen ovale or PFO) can reduce migraine headaches in people who have frequent migraines. You would receive a minimally invasive procedure to close the PFO and take anti-clotting medication afterward.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–54 at the time you start the study
- Diagnosis of migraine (with or without aura) for at least 1 year, starting before age 40
- At least one migraine headache per week on average, either without preventive medication or despite taking preventive medication
- If you take migraine-prevention medication, the dose must be stable for 3+ months before enrollment and stay the same during the first 4 months of the study
- No history of stroke, mini-stroke (TIA), or brain bleeding
- No current pacemaker or other heart devices, no uncontrolled heart rhythm problems, and no other major heart conditions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a device called CeraFlex PFO Occluder to close a small hole in the heart (PFO) that may be causing migraines or strokes. If you have a PFO with related symptoms, the device might help prevent future events.
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