Closing a heart hole to treat migraines
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This trial tests whether closing a small hole in the heart (called a PFO) can help eliminate migraines. If you have frequent migraines and no other major health issues, this procedure might reduce or stop your headaches.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 55 years old.
- You must have had migraines (with or without aura) for at least 1 year, and they started before age 40.
- You must have more than one migraine day per week on average (without treatment, despite treatment, or because you stopped treatment due to side effects or cost).
- You cannot have had a stroke, TIA (ministroke), or bleeding in the brain.
- You cannot have other heart defects or devices, like a pacemaker or a previous PFO closure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if closing a common heart defect (PFO) can improve migraine symptoms and brain function. It compares people with migraine who get the closure procedure to those without migraine.
This trial tests a device called the Snowy PFO Closure System, which is meant to close a small hole in the heart (PFO) that can let blood clots pass to the brain and cause strokes or migraines. The device is inserted through a small tube, and the study aims to see if it is safe and works well.
This study is for people who have migraines and a small hole in their heart called a patent foramen ovale (PFO). It will track your health over time to learn more about how these conditions are related.
This trial looks at the safety and results of closing a PFO (a small hole in the heart) in people who have had a stroke or embolism with no other clear cause. If you qualify, doctors will close your PFO using a small tube inserted through a blood vessel and then follow your health over time.
This study tests a device called CeraFlex PFO Occluder to close a small hole in the heart (PFO) that may be causing migraines or strokes. If you have a PFO with related symptoms, the device might help prevent future events.
This study looks at the detailed flow pattern through a patent foramen ovale (PFO)—a small opening in the heart—and how it may relate to stroke, TIA, or migraine. Doctors use special ultrasound testing with contrast to better understand who is most affected.
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