Clin2
NCT07631793Possibly a fitRecruiting

Experimental vaccine for advanced solid tumors

Malignant Neoplasms

Part of Cancer clinical trials.

This trial tests an experimental vaccine called YKYY031 for people with advanced solid tumors that have stopped responding to standard treatments. The vaccine aims to help your immune system fight cancer cells that carry specific markers. It may be an option if you have certain genetic markers and tumor proteins.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
76 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You must be between 18 and 75 years old.
  • You must have an advanced or metastatic solid tumor (like colorectal or pancreatic cancer) that has failed standard therapy.
  • You must have the HLA-A*11:01 genetic marker (a blood test can check this).
  • Your tumor must test positive for at least one of the specific tumor proteins targeted by the vaccine.
  • You should be feeling relatively well (able to do light activities) and have a life expectancy of at least 3 months.
  • You need at least one measurable tumor lesion (a tumor that can be seen on scans).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07139067Recruiting· Phase 1
YK1101 for advanced solid tumors

This trial tests a new cell therapy called YK1101 for people with advanced solid tumors that have not responded to standard treatment. It targets a specific protein (MAGE-A4) on cancer cells and requires a matching genetic type called HLA-A*11:01.

Beijing
NCT07482319Not yet recruiting· Phase 1
Immune cell therapy for advanced solid tumors that have not responded to treatment

This trial tests an experimental treatment called GK01, which uses your own immune cells (called tumor-infiltrating lymphocytes) that have been taken from your tumor, multiplied in a lab, and given back to you. It is for people with advanced solid tumors that have not responded to standard treatments, and aims to see if these cells can shrink your cancer.

Beijing
NCT07412665Not yet recruiting· Early Phase 1
Immune cell study for advanced solid tumors

This study tests an investigational cell therapy (GK01) for people with advanced solid tumors that have grown despite standard treatment or have no standard treatment option. It may help shrink tumors or slow their growth.

Beijing
NCT07567222Recruiting· Phase 1
Vaccine therapy for advanced solid tumors

This study tests a new therapeutic vaccine designed to help your immune system fight advanced solid cancers. You would receive vaccine injections alongside standard cancer care if your cancer has progressed despite previous treatments.

Chengdu, Sichuan
NCT05749627Recruiting
Vaccine for advanced cancers using your tumor’s targets

This trial tests a personalized vaccine made from “neoantigens” (tumor-specific targets) to help your immune system fight advanced, inoperable solid tumors. It may be an option if standard treatment didn’t work or you stopped it and your health is strong enough for trial treatment.

Nanchang, Jiangxi
NCT07182435Not yet recruiting· Early Phase 1
Personalized mRNA vaccine for advanced solid tumors

This trial tests a personalized mRNA vaccine (RH125) designed to train your immune system to attack your cancer. It is for people with advanced solid tumors that have not responded to standard treatments, and it aims to see if the vaccine is safe and helpful.

Shenzhen, Guangdong

Hear when a new Malignant Neoplasms trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.