Brain Chemistry Study in Young People with Friedreich's Ataxia
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This study looks at two brain chemicals (GABA and glutathione) in children and teens aged 8–15 with Friedreich's ataxia, a rare genetic condition affecting movement and coordination. The research aims to understand how these chemicals change in the brain and may help guide future treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 8 and 15 years old
- You have a confirmed genetic diagnosis of Friedreich's ataxia with specific GAA repeat mutations in the FXN gene
- Your Friedreich's ataxia symptoms are mild to moderate (specific disease severity score ≤ 65)
- You can understand and follow English instructions
- You do not have a pacemaker, metal implants, or metal dental braces (needed for the brain MRI scan)
- You are not currently pregnant and can participate in study visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study uses heart tests (including ultrasound and MRI) to better understand how Friedreich’s ataxia affects the heart. You might benefit by getting detailed heart evaluation and contributing to research that could guide future care.
This study tests a new medicine called GV101 to see if it can help people with Friedreich's ataxia, a condition that affects movement and balance. The trial will check if GV101 is safe and if it improves symptoms.
This study looks at how the heart works during exercise and how that relates to fatigue in people with Friedreich's ataxia. You'll ride a stationary bike, and we'll measure your heart's output to understand fatigue better.
This study uses an EEG (a painless test that records your brain's electrical activity) to map the brain connections in people with Friedreich's ataxia. It aims to better understand how the condition affects the brain.
This study looks at “biomarkers” (measurable signs in the body, like test results from blood or other checks) in people with Friedreich’s ataxia. It may help researchers understand the disease better and track changes over time.
This study tests an investigational drug given as a daily injection to see if it can improve walking and balance in people with Friedreich's ataxia.
Hear when a new Friedreich's Ataxia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.