Doxapram to Help Breathing During Ventilator Weaning
Treatments studied
Part of Lungs & breathing clinical trials.
This study tests whether a medication called doxapram can improve how well your diaphragm (the main breathing muscle) works as you're being taken off a breathing machine. Stronger diaphragm movement may help you breathe more easily on your own.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old and have been on a mechanical ventilator (breathing machine) for more than 2 days
- Your medical team must agree you are ready to start coming off the ventilator based on specific breathing and heart stability tests
- Your oxygen levels in the blood must be adequate (PaO₂/FiO₂ ratio greater than 150)
- You cannot have severe brain or spinal cord injury (such as spinal cord injury above the mid-back)
- You cannot be allergic to doxapram or be pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if the drug doxapram can improve diaphragm movement in COPD patients who are being taken off a ventilator during a breathing trial. It aims to make the transition smoother and more successful.
This study uses ultrasound to look at how well your diaphragm (the main breathing muscle) is working while you are on a breathing machine. The goal is to see if this can help doctors predict when you can safely breathe on your own and leave the ventilator sooner.
This study uses an ultrasound measure of how your diaphragm (the muscle that helps you breathe) moves in coordination as a way to predict whether you can successfully come off the breathing machine. If you are ready to try breathing on your own with a support mode, the test may help doctors know when you are truly ready to be free of the ventilator.
This study tests if special exercises or other treatments can help patients whose diaphragm (the main breathing muscle) becomes weak after being on a breathing machine for two days or more.
This trial tests a non-drug breathing technique to help people who are having trouble coming off the breathing machine in the ICU. If you have needed a ventilator for more than a day and have already failed a breathing trial, this study may be for you.
This trial checks if the way your diaphragm moves can help doctors know when you're ready to come off a breathing machine (mechanical ventilation). It focuses on patients who have been on the machine for more than 72 hours.
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